abstract：:In this paper, a deterministic model characterizing the within-host infection of Hepatitis C virus (HCV) in intrahepatic and extrahepatic tissues is presented. In addition, the model also includes the effect of the cytotoxic T lymphocyte (CTL) immunity described by a linear activation rate by infected cells. Firstly, ...

authors： Hu X,Li J,Feng X

更新日期：2021-12-01 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) remains a global pandemic at present. Although the human-to-human transmission route for this disease has been well established, its transmission mechanism is not fully understood. In this paper, we propose a mathematical model for COVID-19 which incorporates multiple transmissi...

authors： Yang C,Wang J

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Neutrophil extracellular traps (NETs) represent a novel cellular mechanism of antimicrobial defense activity. Intravascular neutrophils produce extracellular web-like structures composed of chromatin, histones, and cytoplasmic granule proteins to attack and kill microbes. They may impact both pathogen and ho...

authors： Flanders AJ,Ossiboff RJ,Wellehan JFX Jr,Alexander AB,Fredholm DVE,Desiderio TM,Stacy NI

更新日期：2021-12-01 00:00:00

abstract：Background:Heterogeneous government responses have been reported in reaction to COVID-19. The aim of this study is to generate an exploratory review of healthcare policies published during COVID-19 by health-care institutions in Mexico. Analyzing policies within different health sub-systems becomes imperative in the Me...

authors： Bautista-González E,Werner-Sunderland J,Pérez-Duarte Mendiola P,Esquinca-Enríquez-de-la-Fuente CJ,Bautista-Reyes D,Maciel-Gutiérrez MF,Murguía-Arechiga I,Vindrola-Padros C,Urbina-Fuentes M

更新日期：2021-12-01 00:00:00

abstract：:Stem cells could form the basis of a novel, autologous treatment for chronic wounds like diabetic foot ulcers. Fat grafts contain adipose-derived stem cells (ADSC) but low survival of cells within the grafts is a major limitation. Platelet-rich plasma (PRP) may increase graft survival. This review examines the histolo...

authors： Nolan GS,Smith OJ,Jell G,Mosahebi A

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate the correlations of long non-coding RNA ANRIL (lncRNA ANRIL), microRNA (miR)-34a, miR-125a and miR-186 with disease risk, clinical features and prognosis of multiple myeloma (MM). METHOD:Totally, 87 MM patients and 30 controls were recruited. LncRNA ANRIL and its target miRNAs...

authors： Yin Y,Yang W,Zhang L,Liu K,Luo Z

更新日期：2021-12-01 00:00:00

abstract：:Economic crises throughout history have often given an impetus for health and social reforms leading to the introduction of general healthcare systems and social equality in a large number of countries. The aim of this paper is to present the major economic crises and their effect on healthcare and social system chron...

authors： Kaštelan S,Kasun B,Kaštelan U,Radonjić M,Sopta M

更新日期：2021-12-01 00:00:00

abstract：:Norepinephrine (NE), the stress hormone, stimulates many bacterial species' growth and virulence, including Escherichia coli. However, the hormone's impact on the adherent-invasive E. coli (AIEC) implicated in Crohn's disease is poorly understood. In the study, we have investigated the effect of NE on the interaction ...

authors： Beata S,Michał T,Mateusz O,Urszula W,Choroszy M,Andrzej T,Piotr D

更新日期：2021-12-01 00:00:00

abstract：:A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results indicated that the xanthone derivatives possessed good AChE inhibitory activity with eleven of them (5, 8, 11, 17, ...

authors： Loh ZH,Kwong HC,Lam KW,Teh SS,Ee GCL,Quah CK,Ho ASH,Mah SH

更新日期：2021-12-01 00:00:00

abstract：:Objectives: In obesity, there is a shift in the pro-oxidative-antioxidant balance towards the oxidationreactions. However, it has been shown that in people with normal body composition, after a series of whole-body cryotherapy (WBC), the balance shifts in the opposite direction. Design: The aim of the study was to ass...

authors： Pilch W,Wyrostek J,Piotrowska A,Czerwińska-Ledwig O,Zuziak R,Sadowska-Krępa E,Maciejczyk M,Żychowska M

更新日期：2021-12-01 00:00:00

abstract：:The introduction of Bruton's tyrosine kinase inhibitor ibrutinib has made a significant progress in the treatment of chronic lymphocytic leukemia and other B-cell malignancies. Due to the reduction of cytokine release, it is effective in chronic graft-versus-host disease, and its use has also been suggested in autoimm...

authors： Markóth C,File I,Szász R,Bidiga L,Balla J,Mátyus J

更新日期：2021-12-01 00:00:00

abstract：:The consumption of exogenous antioxidants isolated from herbal extracts has shown beneficial effects on ameliorating dialysis-related complications through debilitating oxidative stress and inflammatory process. Many clinical studies available in public databases have reported the improved consequences of dialysis in ...

authors： Asgharpour M,Alirezaei A

更新日期：2021-12-01 00:00:00

abstract：:This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limi...

authors： Cao L,Shao G,Ren F,Yang M,Nie Y,Peng Q,Zhang P

更新日期：2021-12-01 00:00:00

abstract：:Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by another group. We review the anion CA inhibitors (CAIs) in the more g...

authors： Nocentini A,Angeli A,Carta F,Winum JY,Zalubovskis R,Carradori S,Capasso C,Donald WA,Supuran CT

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to determine the effects of two different types of single cardiac rehabilitation (CR) exercise modes on the inflammation status, oxidative stress and total antioxidant capacity (TAC) of saliva. METHODS:The study involved two groups of CR patients: group A (n = 21) used a cycloergome...

authors： Gawron-Skarbek A,Chrzczanowicz J,Nowak D,Gawor R,Kostka T

更新日期：2021-12-01 00:00:00

abstract：:A large number of microbes exist in the gut and they have the ability to process and utilize ingested food. It has been reported that their products are involved in colorectal cancer development. The molecular mechanisms which underlie the relationship between gut microbial products and CRC are still not fully underst...

authors： Fang Y,Yan C,Zhao Q,Xu J,Liu Z,Gao J,Zhu H,Dai Z,Wang D,Tang D

更新日期：2021-12-01 00:00:00

abstract：:Morbidity and mortality of non-AIDS-defining diseases (NADs) have become the increasing burden of people living with HIV (PLWH) with long-term antiretroviral therapy (ART). We aimed to quantify the contribution of modifiable risk factors to NADs. We included PLWHs starting ART at the Third People's Hospital of Shenzhe...

authors： Liu J,Hou Y,Sun L,Wang L,He Y,Zhou Y,Xu L,Liu X,Zhao F,Zhang L,Wang H,Wang FS

更新日期：2021-12-01 00:00:00

abstract：:Chrysophanol shows promising antitumor activity, but how it may work against malignant meningioma is poorly understood. In addition, osteoglycin (OGN) may help mediate the antitumor effects of chrysophanol; thus, this study investigated the potential antitumor mechanism of chrysophanol in malignant meningioma cultures...

authors： Wang J,Lv P

更新日期：2021-12-01 00:00:00

abstract：:Previous researches have suggested that exosomal miRNA-141 has association with metastatic lung cancer, however, its role and regulatory mechanism require further study. In this study, exosomes were isolated from lung cancer patients and normal human serum and identified. We found that the expression of miRNA-141 was ...

authors： Wang W,Hong G,Wang S,Gao W,Wang P

更新日期：2021-12-01 00:00:00

abstract：:This study deals with facile and rapid synthesis of silver nanoparticles (AgNPs) and Gold nanoparticles (AuNPs) using Mentha longifolia leaves extracts (MLE). The synthesized AgNPs and AuNPs were characterized by UV-visible spectroscopy (UV-Vis), Fourier transformed infra-red spectroscopy (FT-IR), atomic force microsc...

authors： Rauf A,Ahmad T,Khan A,Maryam,Uddin G,Ahmad B,Mabkhot YN,Bawazeer S,Riaz N,Malikovna BK,Almarhoon ZM,Al-Harrasi A

更新日期：2021-12-01 00:00:00

abstract：:The knowledge of genetic variation in Chinese patients with non-small-cell lung cancer (NSCLC) is still limited. We aimed to profile this genetic variation in 206 Chinese patients with NSCLC using next-generation sequencing. Tumor tissues or whole-blood samples were collected and subjected to whole-exome targeted next...

authors： Zheng S,Wang X,Fu Y,Li B,Xu J,Wang H,Huang Z,Xu H,Qiu Y,Shi Y,Li K

更新日期：2021-12-01 00:00:00

abstract：:Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in acute myelogenous leukemia (AML) and the mutation is associated with poor prognosis of patients. Two distinct types of activating mutations have been identified in AML samples. One is internal tandem duplications in the juxtamembrane doma...

authors： Kondo T,Onozawa M,Fujisawa S,Harada S,Ogasawara R,Izumiyama K,Saito M,Morioka M,Mori A,Teshima T

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Based on a quality assurance initiative of the German Society for Thoracic and Cardiovascular Surgery (DGTHG) and the German Society for Pediatric Cardiology and Congenital Heart Defects (DGPK), a voluntary registry was founded for assessment of treatment and outcomes of patients with congenital heart diseas...

authors： Beckmann A,Dittrich S,Arenz C,Krogmann ON,Horke A,Tengler A,Meyer R,Bauer UMM,Hofbeck M,German Quality Assurance \/ Competence Network for Congenital Heart Defects Investigators.

更新日期：2021-12-01 00:00:00

abstract：:Synaptojanin 2 (SYNJ2) regulates cell proliferation and apoptosis via dephosphorylating plasma membrane phosphoinositides. Aim of this study is to first seek the full-scale expression levels and potential emerging roles of SYNJ2 in hepatocellular carcinoma (HCC). We systematically analyzed SYNJ2 mRNA expression and pr...

authors： Zhang R,Mo WJ,Huang LS,Chen JT,Wu WZ,He WY,Feng ZB

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of minimal residual disease (MRD) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) on the outcome of acute leukemia. METHODS:Data from 114 patients who were diagnosed with acute leukemia (AL) and underwent allo-HSCT between Jan 2013 and Dec 2019 were collected a...

authors： Shen X,Pan J,Qi C,Feng Y,Wu H,Qian S,Lu H,Chen L,Li J,Miao K,Qiu H,Zhu H

更新日期：2021-12-01 00:00:00

abstract：:Without modern medical management and vaccines, the severity of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) might approach the magnitude of 1894-plague (12 million deaths) and 1918-A(H1N1) influenza (50 million deaths) pandemics. The CO...

authors： To KK,Sridhar S,Chiu KH,Hung DL,Li X,Hung IF,Tam AR,Chung TW,Chan JF,Zhang AJ,Cheng VC,Yuen KY

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:To explore the mechanism of calcium-sensing receptors (CaSRs) during the development of nephrolithiasis. MATERIALS AND METHODS:Wistar rats were treated with ethylene glycol to induce calcium oxalate crystallization, and gadolinium chloride (GdCl3, an agonist of CaSR) and NPS 2390 (an antagonist of CaSR) wer...

authors： Li X,Chen S,Feng D,Fu Y,Wu H,Lu J,Bao J

更新日期：2021-12-01 00:00:00

abstract：:We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA), biodegradable dendrigraft poly-L-lysine (DGL), and γ-polyglutamic acid (γ-PGA), the selective uptake of which by the spleen has already been demonstrated. The ternary ...

authors： Kodama Y,Tokunaga A,Hashizume J,Nakagawa H,Harasawa H,Kurosaki T,Nakamura T,Nishida K,Nakashima M,Hashida M,Kawakami S,Sasaki H

更新日期：2021-12-01 00:00:00

abstract：:Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero tempera...

authors： Eklund L,Schagatay F,Tufvesson E,Sjöström R,Söderström L,Hanstock HG,Sandström T,Stenfors N

更新日期：2021-12-01 00:00:00

abstract：:Poor quality person-centred maternity care (PCMC) leads to delays in care and adverse maternal and newborn outcomes. This study describes the impact of spreading a Change Package, or interventions that other health facilities had previously piloted and identified as successful, to improve PCMC in public health facilit...

authors： Sudhinaraset M,Giessler K,Nakphong MK,Roy KP,Sahu AB,Sharma K,Montagu D,Green C

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:The present meta-analysis was performed to evaluate the efficacy, toxicities of both hypomethylating agents (decitabine and azaciticine) in the treatment of CMML patients. METHODS:All available cohort studies of patients with CMML treated with decitabine and azacitidine were identified. The primary endpoint...

authors： Xu R,Li M,Wu P,Deng C,Geng S,Huang X,Weng J,Du X

更新日期：2021-12-01 00:00:00

abstract：:African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses. In this study, we conducted in silico screening against the colc...

authors： Sirakanyan S,Arabyan E,Hakobyan A,Hakobyan T,Chilingaryan G,Sahakyan H,Sargsyan A,Arakelov G,Nazaryan K,Izmailyan R,Abroyan L,Karalyan Z,Arakelova E,Hakobyan E,Hovakimyan A,Serobian A,Neves M,Ferreira J,Ferreira F,Z

更新日期：2021-12-01 00:00:00

abstract：:In patriarchal societies like Kenya, understanding men's perceptions and attitudes on family planning is critical given their decision-making roles that affect uptake of contraception. Yet, most programmes mainly target women as primary users of contraceptive methods since they bear the burden of pregnancy. However, w...

authors： Abdi B,Okal J,Serour G,Temmerman M

更新日期：2021-12-01 00:00:00

abstract：:During the spring semester of 2020, medical school anatomists in China were forced by the COVID-19 pandemic to transition from face-to-face educators or part-time online educators to full-time online educators. This nationwide survey was conducted to assess online anatomy education during the pandemic for medical stud...

authors： Yan Y,Cheng X,Zhou C,Yang X,Li YQ

更新日期：2021-12-01 00:00:00

abstract：:X-Atlas™ is a new imaging technology intended to advance the state of the art in patient-specific instrumentation. It uses standard AP and lateral radiographs instead of CT or MRI scans to create 3D bone models, which can be used to perform pre-operative surgical planning and fabricate TKA personalized guides. The aim...

authors： Massé V,Ghate RS

更新日期：2021-12-01 00:00:00

abstract：:Neuronal apoptosis was considered as one of the main factors of cerebral ischemia/reperfusion injury. Understanding the molecular regulatory mechanism of neuronal apoptosis under the cerebral ischemia/reperfusion injury may provide the novel therapeutic targets for cerebral ischemia/reperfusion injury. However, the mo...

authors： Liu X,Wang X,Zhang L,Zhou Y,Yang L,Yang M

更新日期：2021-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive and memory-related impairment. However, current therapeutic treatments have not proved sufficiently effective, mainly due to the complicated pathogenesis of the disease. In this study, a nano-formula...

authors： Wang K,Wang L,Chen L,Peng C,Luo B,Mo J,Chen W

更新日期：2021-12-01 00:00:00

abstract：:A new series of quinoline derivatives of combretastatin A-4 have been designed, synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds showed significant antiproliferative activities, among them, 12c exhibited the most potent inhibitory activity against different cancer cell lines (MC...

authors： Ibrahim TS,Hawwas MM,Malebari AM,Taher ES,Omar AM,Neamatallah T,Abdel-Samii ZK,Safo MK,Elshaier YAMM

更新日期：2021-12-01 00:00:00

abstract：:Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus Ebolavirus, CFRs of ebolavirus infections vary...

authors： Yamaoka S,Ebihara H

更新日期：2021-12-01 00:00:00

abstract：:We report here an imported case of SARS-CoV-2 variant of concern B.1.1.351 (also known as 20H/501Y.V2 or "South African variant" or VOC 202012/02) in a 66-years old symptomatic male who returned from Malawi to Italy. ...

authors： Novazzi F,Genoni A,Spezia PG,Focosi D,Zago C,Colombo A,Cassani G,Pasciuta R,Tamborini A,Rossi A,Prestia M,Capuano R,Gasperina DD,Dentali F,Severgnini P,Ageno W,Gambarini C,Stefanelli P,Baj A,Maggi F

更新日期：2021-12-01 00:00:00